UZITEL-A (Telmisartan 40mg + Amlodipine 5 mg Tablets)
Telmisartan 40mg + Amlodipine 5 mg Tablets– Telmisartan and amlodipine combination is used to treat high blood pressure( Hypertension).
Mechanism of Action – Telmisartan
It is an Angiotensin receptor blocker (ARB).
It blocks the action of angiotensin
It acts by relaxing blood vessels thereby reducing the Blood pressure.
Mechanism of Action – Amlodipine
It is an Calcium channel blocker.
It blocks the movement of calcium into cells of heart and blood vessels as result of this blood vessels dilate and decrease the blood pressure.
Advantage of using Telmisartan and Amlodipine
When a single agent cannot control blood pressure because it has reached the highest dose or due to side effects at high dose then two agents are added to take advantage of combination.
The likelihood of achieving systolic blood pressure is 79% and reducing the diastolic is 55%.
Uses of Telmisartan 40mg + Amlodipine 5 mg (Tablets)–
- Hypertension
- Prevention of Strokes by lowering Blood Pressure
- Prevention of Heart Attacks by lowering Blood Pressure
How to use Telmisartan and Amlodipine
It may be taken before or after food
How long does it take to give full effect?
It takes about 4 weeks to give full effect.
Precautions —
Do not use it during pregnancy or if planning to get pregnant.
Side effects of Amlodipine
- Pedal edema- swelling in the ankle region.
Serious Side effects–
- Dizziness/Headache/Light Headed due to hypotension
- Fainting
- Hyperkalemia :
Muscle weakness due to Increased Potassium levels
Slow or Irregular heart beat
- Allergic reaction
- Weight gain
Drug Interactions:
Aliskiren
Angiotensin receptor blockers
Angiotensin converting enzyme inhibitors
NSAIDS
Digoxin
Lithium
Telmisartan and Amlodipine is available as:
Telmisartan 40 mg + Amlodipine 5 mg tablet.
Telmisartan 40 mg + Amlodipine 10 mg tablet.
Telmisartan 80 mg + Amlodipine 5 mg tablet.
Telmisartan 80 mg + Amlodipine 10 mg tablet.
Things to be monitored while on this drug
Blood Pressure
Renal Function test
Electrolyte levels.
What are problems caused by High Blood Pressure:
High blood pressure increase the workload of the heart because it has to pump blood against higher pressure so it increases the demand of oxygen of heart itself which can lead to Heart Failure.
As a result of high blood pressure if it continues for long time then heart and arteries may not function properly which may lead to high pressure in the arteries supplying brain and result in Stroke.
High BP may lead to Renal Failure.
What tests we should undergo if we have hypertension:
- ECG
- Renal Function test
- Lipid Profile
ECG is done to see the condition of the heart whether high blood pressure has put any effect on the hearts functioning or not.
Renal function test done to ascertain the condition of kidney.
Lipid Profile is done to check the level of Total cholesterol/HD/VLDL/LDL/Triglycerides
Management of Hypertension
- Lifestyle modification: Regular exercise, Healthy eating habits
- Dietary Management
- Medications
